The 6th International Conference on Computer and Information Science and Technology (CIST’21) aims to become the leading annual conference in fields related to computer and information science and technology. The goal of CIST’21 is to gather scholars from all over the world to present advances in the relevant fields and to foster an environment conducive to exchanging ideas and information. This conference will also provide an ideal environment to develop new collaborations and meet experts on the fundamentals, applications, and products of the mentioned fields.